产地:Biomol
货号:BML-PI104-0200
BML-PI104-1000 1 mg
BML-PI104-0200 200 µg
A potent and selective irreversible proteasome inhibitor. Specifically inhibits 26S proteasome (MCP; multicatalytic complex). Blocks proteasome activity by targeting the catalytic β-subunit. Has no effect on serine or cysteine proteases. Induces apoptosis inhuman monoblast U937 cells. Inhibits NF-κB activation by inhibiting IκB degradation (IC50=10 µM). Inhibits the ubiquitin proteasome pathway in cell culture. Inhibits cathepsin A. Upregulates HSP70 and HSP22, suggesting an initial neuroprotective pathway.
Induces neurite outgrowth in Neuro 2A mouse neuroblastoma cells.
Product Specification
Formula: C15H24N2O7S
MW: 376.4
Purity: ≥99%
Appearance: White solid
CAS: 133343-34-7
Source/Host: Synthetic
Solubility: Soluble in water (10mg/ml), 100% ethanol (1mg/ml), methanol, DMSO (20mg/ml), dimethyl formamide (20mg/ml) or acetonitrile (20mg/ml)
Shipping: AMBIENT
Long Term Storage: -20°C
Use/Stability: Organic stock solutions are stable for 3 months when stored at -20°C. Subject to hydrolysis in aqueous buffers. We do not recommend storing aqueous solutons for more than one day.
Handling: Avoid freeze/thaw cycles.
Protect from light.
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