Irreversible, cell-permeable inhibitor of granzyme B (ID50=0.3 µM). Does not inhibit granzyme A. Inhibition of granzyme B with Z-AAD-CMK prevented caspase-3 activation in T cells.
Product Specification
Alternative Name: Granzyme B inhibitor
Formula: C19H24ClN3O7
MW: 442.4
Purity: ≥95% (HPLC)
Appearance: White powder.
Sequence: Benzyloxycarbonyl-Ala-Ala-Asp-chloromethylketone
Solubility: Soluble in DMSO (25mg/ml), 100% ethanol (25mg/ml) and water (20mg/ml).
Shipping: SHIPPED ON BLUE ICE
Long Term Storage: -20°C
Handling: After reconstitution, prepare aliquots and store at -20°C.
Solutions can be stored at -20°C for up to 3 months.
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