产地:Sigma
货号:D1515
规格:10mg
价格:1850
品名:Doxorubicin hydrochloride;Doxorubicin;DOX; Frequently Asked Questions
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Inhibitor of reverse transcriptase and RNA polymerase; immunosuppressive agent; intercalates in DNA.
Biochem/physiol Actions
Antitumour antibiotic. Effect of adriamycin® on heart mitochondrial DNA;1 Properties.2,3
Naturally fluorescent anthracycline antibiotic, anticancer drug. Doxorubicin is a substrate of MRP1 which was first cloned from a DOX-resistant lung cancer cell line. Fluorescent property has been exploited for the measurement of drug efflux pump activities as well as resolving the important question of intracellular localization of various multidrug resistance proteins and the role of subcellular organelles (Golgi and lysosome) in the sequestration of drugs and its implication in drug resistant phenotypes.