ApolipoproteinCIII(APOC3)antibody

Apolipoprotein CIII(APOC3)antibody
Cat.#: 3125-1
Rabbit Monoclonal Antibody
Clone ID: EPR1371(2)
Swiss Prot: P02656
Mol Weight: 11kDa
Size: 100ul

Description
Apolipoprotein CIII (Apo CIII) is one of 9 known polymorphic forms of apolipoproteins. The apolipoproteins function as stabilizers of intact lipoprotein particles. Specifically, Apo CIII is a very low density lipoprotein (VLDL) protein (1). Apo CIII is involved in inhibition of lipoprotein and hepatic lipases. It is thought to delay catabolism of triglyceride-rich particles. A defect in Apo CIII has been linked to hyperalphalipoproteinemia (HLAP), which causes increased levels of high density lipoprotein (HDL) (2).

Recommended Applications
WB, IHC

Applications and Recommended Dilution Factors
WB: 1:1,000 - 10,000
IHC: 1:250 - 500

Species Reactivity
Human

Mouse cross reactivity tested by western blot and IHC
Rat cross reactivity tested by western blot only

Products Data 

 

Western blot analysis on (A) human plasma and (B) HDL cell lysates using anti-Apolipoprotein CIII RabMAb (cat. # 3125-1).
Immunohistochemical staining of paraffin-embedded human liver tissue using anti-Apolipoprotein CIII RabMAb (cat. #3125-1).

Specificity
A synthetic peptide corresponding to residues in human Apolipoprotein CIII was used as an immunogen.

Storage Condition and Buffer
Store at -20 °C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

Alternative Names
APOC3 antibody, APOCIII antibody, MGC150353 antibody, Apolipoprotein C-III antibody, Apolipoprotein C3 antibody

Description References
1. Hirano, T, et al; Kidney International 63:2171–2177, 2003. 2. Hirano, K, et al; Arteriosclerosis, Thrombosis, and Vascular Biology, 15:1849-1856, 1995.