ApolipoproteinF(apoF)(APOF)antibody

Apolipoprotein F(apo F)(APOF)antibody
Cat.#: 2636-1
Rabbit Monoclonal Antibody
Clone ID: EPR2908
Swiss Prot: Q13790
Mol Weight: 33kDa
Size: 100ul

Description
Apolipoprotein F (Apo F), also known as lipid transfer inhibitor protein (LTIP) based on its ability to inhibit lipid transfer between lipoproteins, is a protein component of several lipoprotein classes and a physiologic regulator of cholesteryl ester transfer protein (CETP) function (1, 2). Apo F activity was reported to be localized to LDL, consistent with its greater inhibitory activity on this lipoprotein. Apo F activity is controlled by its reversible incorporation into an inactive complex which provides for short-term fine-tuning of lipoprotein remodeling mediated by CETP (1). ApoF overexpression reduces HDL cholesterol levels by increasing clearance of HDL-CE. ApoF may be an important determinant of HDL metabolism and reverse cholesterol transport (2).

Recommended Applications
WB, ICC

Applications and Recommended Dilution Factors
WB: 1:1000 - 2000
ICC: 1:100 - 250

Species Reactivity
Human, Mouse

Cross reactivity determined by western blot only.

Products Data

A.Western blot analysis on (A) HDL and (B) human plasma lysates using anti-Apolipoprotein F (apo F) RabMAb (cat. #2636-1), dilution 1:2000.

Specificity
A synthetic peptide corresponding to residues in human Apolipoprotein F (apo F) was used as an immunogen.

Storage Condition and Buffer
Store at -20 °C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

Alternative Names
APOF antibody, Apo-F antibody, DKFZp781G18150 antibody, LTIP antibody, MGC22520 antibody, Apolipoprotein F antibody, Lipid transfer inhibitor protein antibody

Description References
1. He Y, et al. J Lipid Res. 49(7):1529-37, 2008
2. Lagor WR, et al. Arterioscler Thromb Vasc Biol. 29(1):40-6, 2008