APP(Abeta38)antibody

APP(Abeta38)antibody
Cat.#: 3591-1
Rabbit Monoclonal Antibody
Clone ID: EPR1878(2)
Swiss Prot: P05067
Mol Weight: 4kDa
Size: 100ul

Description
APP is a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer's disease. Mutations in APP have been implicated in autosomal dominant Alzheimer's disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy) (1).

Recommended Applications
WB, ELISA

Applications and Recommended Dilution Factors
WB: 1:1,000 - 10,000
ELISA: 1 ug/ml

Species Reactivity
Human

Products Data

Western blot analysis on (A) Abeta38, (B) Abeta40, and (C) Abeta42 lysates using anti-Abeta38 recombinant protein RabMAb (cat. #3591-1).

Specificity
A synthetic peptide corresponding to residues in human APP was used as an immunogen.

Storage Condition and Buffer
Store at -20 °C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

Alternative Names
APP antibody, AAA antibody, ABETA antibody, ABPP antibody, AD1 antibody, APPI antibody, CTFgamma antibody, CVAP antibody, PN2 antibody, C31 antibody, Gamma-CTF(50) antibody

Description References
1. Entrez Gene: gene-centered information at NCBI. Nucleic Acids Res. 2005 Jan 1;33:D54-8.