AP2gamma(TFAP2C)antibody

AP2 gamma(TFAP2C)antibody
Cat.#: 2390-1
Rabbit Monoclonal Antibody
Clone ID: EP2692Y
Swiss Prot: Q92754
Mol Weight: 49kDa
Size: 100ul

Description
Transcription factor gene AP2-C (AP-2 gamma) belongs to a family of four closely related genes. The AP-2 transcription factor has been shown to play an important role in the development of tissues of ectodermal origin and has also been implicated in mammary oncogenesis (2). A physical and functional association between AP-2gamma transcription factor and the Wwox protein has been demonstrated. results suggest that Wwox tumor suppressor protein inhibits AP-2gamma oncogenic activity by sequestering it in the cytoplasm (2). P-2 gamma had been implicated in multiple functions during proliferation and differentiation based on its expression pattern in trophoblast, neural crest, and ectoderm cells in murine embryos. AP-2 gamma seems to be required in early embryonic development because it regulates the genetic programs controlling proliferation and differentiation of extraembryonic trophectodermal cells (3).

Recommended Applications
WB, IHC, ICC, FC

Applications and Recommended Dilution Factors
WB: 1:10,000 -50,000
IHC: 1:250 - 500
ICC: 1:100 - 250
FC: 1:50

Species Reactivity
Human

Cross reactivity determined by western blot only.

Products Data 

 

A. Western blot analysis on (A) MCF-7 and (B) SKBR3 cell lysate using anti-AP2-C RabMAb (cat. # 2390-1), dilution 1:50,000.
B. Immunohistochemical analysis of paraffin-embedded human breast carcinoma using anti-AP2C RabMAb. (cat. #2390-1).

Specificity
A synthetic peptide corresponding to residues in human AP2 gamma was used as an immunogen.

Storage Condition and Buffer
Store at -20 °C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

Alternative Names
TFAP2C antibody, AP2-GAMMA antibody, ERF1 antibody, TFAP2G antibody, hAP-2g antibody, Transcription factor AP-2 gamma antibody, Activating enhancer-binding protein 2 gamma antibody, Transcription factor ERF-1 antibody

Description References
1. Williamson JA, et al. Genomics 35(1):262-4, 1996
2. Ageilan RI, et al. Cancer Res 64(22): 8256-61, 2004
3. Werling U et al. Mol Cell Biol 22(9):3149-56, 2002